Inside the main system unit, position of the motherboard depends on the model/type of the cabinet used.
Inside a tower model cabinet, the motherboard is attached to one side of the system box, normally it is placed just below the power supply.
On a Desktop model cabinet, the motherboard is placed at the base of the system box, next to the power supply.
Motherboard is connected to the cabinet with about half inch high plastic spacer in between the board and the cabinet at various places.
This protects the components on the motherboard from touching the cabinet’s bottom metal surface and short circuiting themselves.